Molecular Layer Interneurons: Key Elements of Cerebellar Network Computation and Behavior

• Molecular layer interneurons (MLIs) participate in spatially structured networks via chemical and electrical synapses. Clusters of MLIs converge to control the temporal spatial pattern Purkinje cell activity cerebellum. These MLI circuits mediate a number behavioral functions, including motor coordination learning. play an important role cerebellar information processing by controlling (PC) inhibitory synaptic transmission. A local network, constructed from both synapses, is organized into clusters that amplify feedforward lateral inhibition shape patterns PC activity. Several recent vivo studies indicate such contribute not only sensorimotor processing, but also precise cognitive processes. Here, we review current understanding organization their roles function mammalian